Geetha Chittoor 1, Karin Haack 2, Sandra Laston 3, Nitesh R Mehta 4, Shelley A Cole 2, Anthony G Comuzzie 2, Nancy F Butte 4 and V. Saroja Voruganti 1 (2016). Novel Association Of Estimated Glomerular Filtration Rate With NKAIN2 Gene Variants In Hispanic Children. The FASEB Journal, 30(1).
1. The University of North Carolina at Chapel Hill, Kannapolis, NC
2. Texas Biomedical Research Institute, San Antonio, TX
3. University of Texas at Rio Grande Valley, Brownsville, TX
4. Baylor College of Medicine, Houston, TX
Background: Obesity has been associated with reduced kidney function and increased chronic kidney disease risk, in both adults and children.
Objective: To identify genetic loci contributing to the variation in estimated glomerular filtration rate (eGFR) using genome-wide association (GWAS) approach in 789 Hispanic children of the Viva La Familia Study (VFS).
Methods: We conducted a GWAS using SOLAR after accounting for familial relationships. Empirical thresholds for genome-wide significant and suggestive associations were set at p
Results: Mean± SD values of serum creatinine and eGFR were 1.79 ± 0.97 mg/dL and 39.3 ± 14.7 mL/min/1,73m2, respectively, and were significantly different (p <3×10−15) between obese (2.06 ± 1.09; 35.64 ± 14.45) and non-obese children (1.52 ± 0.75; 43.02 ± 13.82). eGFR, adjusted for age, age*sex, and BMI z-scores, was significantly heritable (51%, p <1×10−16). The GWAS identified rs2689886 (p
Conclusions: Children and adolescents, particularly obese, of the VFS exhibit significantly lower eGFR. Additionally, for the first time, we have shown the association of the NKAIN2 gene with eGFR and serum creatinine in Hispanic children warranting future functional studies pertaining to this gene and renal function in pediatric cohorts.