Appalachian State

Joint Pain? ASU Needs You for a Study

April 09, 2013

Released by Appalachian State University

Individuals between the ages of 50 to 75 are being recruited for a study on joint pain and function being conducted by Appalachian State University’s Human Performance Laboratory at the North Carolina Research Campus in Kannapolis.

The study will look at the influence of a leading plant-based joint support supplement on joint pain, stiffness, function and inflammation. Dr. David C. Nieman, director of the laboratory, will lead the study.

Those completing the study will receive $300.

According to Nieman, joint pain is reported by 28 percent of U.S. adults and increases with age. “There is increasing interest in the use of supplements based on natural plant components to alleviate symptoms related to joint pain,” he said. “The joint support supplement to be used in this study is a unique mix of eight ingredients that may relieve joint pain discomfort, improve joint range of motion, and increase mobility.”

The joint support supplement is a leading product throughout the U.S., but the formula has not yet been tested in humans using a randomized, double-blinded, placebo-controlled research design. The study will assess the effect of eight weeks ingestion of the supplement compared to placebo on joint pain, stiffness, inflammation, and function in adults with self-reported joint pain.

Those interested in volunteering for the study should have a three-month or greater history of joint pain in the knees, hip, ankles, shoulders or hands; no history of regular use of non-steroidal anti-inflammatory (NSAIDS) drugs during the two weeks prior to the study,  and a willingness to avoid NSAIDs use during the study.

Additional information and requirements follow. To sign up for the study or for more information, email ASU-NCRC@appstate.edu or call 704-250-5351.

 

What is the purpose of this research?

The primary purpose of this study is to assess the effect of 8-weeks ingestion of the joint support supplement compared to placebo on joint pain, stiffness, inflammation, and function in adults with self-reported joint pain.

Who can take part in this research?

A total of 110 male or female participants who meet the following criteria:
1.  Age 50-75 years.
2.  History (>3 months) of joint pain in the knees, hip, ankles, shoulders, or hands.
3.  No history of regular use of non-steroidal anti-inflammatory drugs (NSAIDs) use (e.g., ibuprofen, aspirin) during the previous two weeks, and willingness to avoid NSAIDs use during the 8-week study.
4.  Not on other medications (e.g., analgesic gels, arthritis medications, other anti-inflammatory drugs) or supplements (in particular, glucosamine and chondroitin) for joint pain for the previous two weeks, and willingness to avoid use of these during the 8-week study.
5. No serious medical problems (current cancer case, severe rheumatoid arthritis, recent heart attack, recent stroke, congestive heart failure, ulcers, kidney disease, or other disease that will interfere with study participation).
6.  No psychiatric disorder or other condition that might interfere with self-assessment ability.
7.  Willingness to stay weight stable during the study.
8.  Willingness to follow all study procedures, including randomization to one of two groups.
9.  Able to walk for at least 6 minutes at a moderate-to-brisk pace.
10.  Body weight of 110 pounds or more.
11.  No history of allergic reactions to products containing shellfish components and aspirin.

What will people in the study be asked to do?

The research procedures will be conducted through the Human Performance Laboratory (Room 1201, Plants for Human Health Institute Building, 600 Laureate Way), operated by Appalachian State University at the North Carolina Research Campus (NCRC) in Kannapolis, NC. Participants will need to come to the YMCA in Kannapolis (101 YMCA Drive, Kannapolis, 28081) two times during the 8-week study (pre-study, and then 8 weeks later for post-study testing). Each test session will take about 1.5 hours, and will include blood samples of 35 ml (a little over 2 tablespoons). The total amount of time needed to volunteer for this study is about 3 hours at the YMCA in Kannapolis.

This study will follow a strict research design.  Participants will be randomized to one of two groups:  the joint support supplement or placebo.  The supplement will be ingested daily for 8 weeks. Participants will not know the type of supplement (joint support supplement vs. placebo) being consumed until after the study is over.  Measurements will be taken pre- and post-study, and will include several validated questionnaires to assess self-reported joint pain, a 6-minute walk test to assess function, and blood samples that will be assayed for inflammation.  This study will determine the efficacy of the joint support supplement in alleviating symptoms and systemic inflammation in subjects with joint pain.
– See more at: http://www.ncresearchcampus.net/news-and-information/news/ncrc-news/got-joint-pain-asu-needs-you-for-a-study#sthash.uQKqBVuR.dpuf

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