NCRC RESEARCH CENTERS

Duke Clinical and Translational Science Insitute

Newby Duke CTSI

L. Kristin Newby, MD, MHS, principal investigator of the MURDOCK Study and lead faculty for the Duke CTSI Translational Population Health Research Group

The Duke Clinical & Translational Science Institute (CTSI) Translational Health Research (TransPop) is a highly productive team of clinical research cooordinators, project managers, data techhnicians and regulatory, community engagement and adminisstrative staff in Kannpapolis. The team supports numerous studies, including the 12,400-participant MURDOCK Study community engagement registry and biorepository.

The team continually increases knowledge through clinical research training, conferences and presentations of MURDOCK Study recruitment strategies. Their goal is to enable research opportunities that will lead to improvement in the health and well-being of the public.

Capabilities

CTSI TransPop offers collaborators:

  • Proposals and budget development
  • Cohort identification
  • Community engagement and recruitment
  • Project leadership
  • Regulatory support
  • Spanish language translation
  • Data management
  • Marketing and communications
  • Clinical operations
  • Biospecimens and biobanking

MURDOCK Study Innovation

Today, more than 12,400 participants are being followed longitudinally for health outocmes, and their data and biospecimens are available to researchers through a simple process. The diverse cohorts and in-person follow-up visits of MURDOCK Study participants can be leverage by investigators to further understand heart, lung, blood, and sleep disease and disorders. TransPop expertise in collecting EHR data and belief in collaborative team-based science allows us to support research across the translational spectrum.

MURDOCK Study nestsed cohorts are valuable in studies such as:

  • COPD: To better understand the progression of COPD symptoms in a community.
  • Multiple Sclerosis: To identify molecular signatures that can be used to better predict the onset and progression of MS.
  • 30 and older: To improve knowledge about the physical, environmental, genetic and omic factors that contribute to age-relate changes.
  • 55 and older: To better understand the role of aging in changes to memeory and thinking.
  • PCORI/UAMS: To understand the corrleation between participant-reported medical conditions and medical record documentation.

Current Collaborations

TransPop’s newest study, Project Baseline, was launched in 2017 as a collaboration between Verily, Duke University School of Medicine, Stanford Medicine, and Google. The Project Baseline study is an observational study that will collect, organize, and analyze broad health data from approximately 10,000 participants over the course of at least four years. The study is designed to develop a well-defined reference, or “baseline,” of good health, as well as a rich data platform that may be used to better understand the transition from health to disease.

Participants will join together with a team of experts from across academia, medicine, science, technology, engineering, and design to better understand how health can change over time. Participants will be asked to visit a study site up to four times yearly, test new technologies and wearable devices daily, and participate in interactive surveys and diaries by using a smartphone, computer, or call center. Data collected will include clinical, imaging, self-reported, physical, environmental, behavioral, sensor, molecular, genetic, and other health-related measurements. Biospecimens collected will include blood and saliva, among others. Learn more.

Other collaborations:

  • Metabolic signatures underlying vascular risk factors for Alzheimer-type dementia, funded by NIH
  • Diabetes Self-management and Support LIVE Study, funded by NIH
  • Assessing the Quality of EHR Data and Participants-reported Data, funded by PCORI.

To learn more, visit DukeTransPop.org.

 

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