David H. Murdock Research Institute Search Results

NCRC Science Stop is a New Addition at Jiggy with a Piggy

Kannapolis, NC- The annual Jiggy with a Piggy Festival is this weekend in downtown Kannapolis. Scientists and staff from the research centers at the NC Research Campus are joining the fun on Saturday, May 6 from 10 am to 2 pm at the NCRC Science stop. Children and their families will find the Science Stop […]

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New Gene Interaction Appears to be Associated with Increased MS Risk

Read the article by Sarah Avery, Duke Health, or on the website of the Kannapolis office of the Duke Clinical and Translational Science Institute. MURDOCK Study samples were used in research findings  published in the journal Cell that could open the way to the development of more accurate tests for risk of multiple sclerosis.   DURHAM and […]

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MURDOCK-NCRC Seed Funding Voucher Awardees

The MURDOCK Study has awarded six $10,000 vouchers as part of the MURDOCK-NCRC Seed Funding Voucher Program to investigators from North Carolina Research Campus partners. Duke University and the MURDOCK Study are pleased to announce the following voucher recipients: Saroja Voruganti, PhD, UNC Nutrition Research Institute (UNC NRI) “A pilot study to identify polymorphisms associated […]

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Wonder of the world- NC’s research, workforce and quality of life attracts biotech

Read the original article from Business North Carolina magazine featuring comments from John Cavanagh, PhD, interim president of the David H. Murdock Research Institute. North Carolina’s reputation for research, workforce and quality of life attracts international biotechnology companies. North Carolina’s biotechnology sector is strong and diverse. It includes almost 700 companies. While about 450 are […]

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Students try their hand at science

By Erin Weeks Read the original story in the Independent Tribune. Puckered lips and screwed-up faces quickly turned into wide-eyed smiles as lemons the students tasted hit their tongues sweet instead of sour. Protein from a particular frozen berry they’d eaten minutes before altered their taste buds, the 12 middle and high schoolers learned, before […]

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GC x GC-MS Newest Service in the DHMRI Metabolomics Laboratory

Read the original story on www.dhmri.org. The David H. Murdock Research Institute (DHMRI) located on the NC Research Campus (NCRC) in Kannapolis, NC recently completed a licensing agreement with the University of Louisville, Kentucky for analytical software that supports two-dimensional gas chromatography mass spectrometry (GC×GC-MS) for metabolite biomarker discovery. The software license allows DHMRI to […]

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The NCRC Opens New Ready-to-Use Laboratory Suites and First Flexible Office

  Kannapolis, NC– Entrepreneurs take note. The NC Research Campus (NCRC) newest ready-to-use wet laboratory suites and its first flexible office space are both open for business. Located on the third floor of the NCRC’s David H. Murdock Core Laboratory Building both of the new 2,000-square-foot research laboratory suites can be sub-divided into smaller units. […]

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David H. Murdock Announces New Castle & Cooke North Carolina Leadership

              Westlake Village, CA – David H. Murdock, the visionary behind the NC Research Campus, announced today that Mark Spitzer, director of human resources for Castle & Cooke, Inc., has been promoted to vice president of North Carolina Operations. “I am strongly committed to the mission of the NC Research […]

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GCxGC-MS Validated for Metabolomics Profiling, Biomarker Discovery

Read the story on Advanced Health Network. Scientists at the David H. Murdock Research Institute (DHMRI), located at the NC Research Campus in Kannapolis, NC, validated the use of comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) for metabolite biomarker discovery. “GC x GC-MS is an approach to biomarker research that tends to be under-used,” commented […]

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Genome‐wide association links candidate genes to resistance to Plum Pox Virus in apricot (Prunus armeniaca)

Genome‐wide association links candidate genes to resistance to Plum Pox Virus in apricot (Prunus armeniaca), New Phytol. 2015 Sep 10, Mariette S1,2,3, Wong Jun Tai F1,4, Roch G5,6, Barre A4, Chague A1, Decroocq S1, Groppi A4, Laizet Y2,3, Lambert P5, Tricon D1, Nikolski M4, Audergon JM5,Abbott AG1,7, Decroocq V1. 1UMR 1332 Biologie du Fruit et Pathologie, Equipe […]

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Dynamics and thermodynamic properties of CXCL7 chemokine

Dynamics and thermodynamic properties of CXCL7 chemokine, Proteins. 2015 Aug 22, Herring CA1, Singer CM1, Ermakova EA2, Khairutdinov BI2, Zuev YF2, Jacobs DJ1,3, Nesmelova IV1,3. 1Department of Physics and Optical Science, University of North Carolina, Charlotte, NC, 28223, USA. 2Kazan Institute of Biochemistry and Biophysics, Kazan, 40111, Russia. 3Center for Biomedical Engineering, University of North Carolina, Charlotte, […]

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Duke Energy Contributes $350,000 to NCRC’s P2EP

Wound-healing properties of oats and the nutritional content of cooked versus uncooked broccoli are just two of the research projects David Phillips, district manager with Duke Energy North Carolina, learned about when he visited the NC Research Campus’ (NCRC) Plant Pathways Elucidation Project (P2EP) on Monday, July 13. Phillips presented $100,000 to P2EP. The check […]

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Duke’s MURDOCK Study offers $100,000 in seed funding to NCRC scientists

  KANNAPOLIS, N.C.—July 2, 2015—Duke University’s MURDOCK Study will invest up to $100,000 in the coming year to fund scientific discoveries at the North Carolina Research Campus (NCRC) in Kannapolis. The MURDOCK Study-NCRC Seed Funding Voucher Program will provide up to 10 vouchers worth $10,000 each to qualifying NCRC investigators from any institution on the […]

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NCRC Offers Start-Ups Advantages

While touring the NC Research Campus (NCRC), founders of a West Coast biotech start-up were impressed to find in one place the resources they need to launch their business: Collaborations exploring plant-based phytochemicals with scientists at the NC State Plants for Human Health Institute. Product testing with the Appalachian State University Human Performance Laboratory, Spectrum Discovery Center and the UNC Nutrition Research Institute’s Human Research Core. […]

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Distribution and biomarker of carbon‐14 labeled fullerene C60 ([14C (U)] C60) in pregnant and lactating rats and their offspring after maternal intravenous exposure

Distribution and biomarker of carbon‐14 labeled fullerene C60 ([14C (U)] C60) in pregnant and lactating rats and their offspring after maternal intravenous exposure,J Appl Toxicol. 2015 Jun 17, Snyder RW1, Fennell TR1, Wingard CJ2, Mortensen NP1, Holland NA2, Shannahan JH2, Pathmasiri W1, Lewin AH1, Sumner SC1. Note: The David H. Murdock Research Institute at the NC […]

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P2EP Kicks Off Third “Summer of Science” at NC Research Campus

The third class of the Plant Pathways Elucidation Project (P2EP) kicked off an 11-week summer of science at the NC Research Campus (NCRC). This year’s class will not only work in teams to research crops including broccoli, blueberries, strawberries and oats, they will also be involved in cooking demonstrations and community outreach, engaging the public with […]

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The plant parasite Pratylenchus coffeae carries a minimal nematode genome

The plant parasite Pratylenchus coffeae carries a minimal nematode genome,  11 Apr 2015, Nematology, Mark BURKE 1,2,3, Elizabeth H. SCHOLL 4, DavidMcK. BIRD 1,4, Jennifer E. SCHAFF 5, Steve COLEMAN 2, Randy CROWELL 6, Stephen DIENER 3, Oksana GORDON 6, Steven GRAHAM 3, Xinguo WANG 6, EricWINDHAM 3, Garron M. WRIGHT 3 and Charles H. OPPERMAN 4, 1 Bioinformatics […]

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Research campus moving past slow start, looking to define future

By Josh Bergeron, Salisbury Post Contact reporter Josh Bergeron at 704-797-4246. Read Original Article The N.C. Research Campus still lags behind initial employment projections, but, as the nation and state recover from an economic recession, growth is beginning to pick up. Following billionaire businessman David Murdock’s $15 million annual endowment last year, the research campus […]

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Comparison of GC-MS and GC× GC-MS in the Analysis of Human Serum Samples for Biomarker Discovery

Comparison of GC-MS and GC× GC-MS in the Analysis of Human Serum Samples for Biomarker Discovery, J Proteome Res. 2015 Mar 4, Winnike JH, Wei X, Knagge KJ, Colman SD, Gregory SG, Zhang X, David H. Murdock Research Institute. Abstract We compared the performance of gas chromatography time-of-flight mass spectrometry (GC-MS) and comprehensive two-dimensional gas chromatography time-of-flight […]

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Proteinuria in Cynomolgus macaques (Macaca fascicularis) with Spontaneously Developed Metabolic Disorder and Diabetes: Transcriptome Analysis of Biopsy Kidney

Proteinuria in Cynomolgus macaques (Macaca fascicularis) with Spontaneously Developed Metabolic Disorder and Diabetes: Transcriptome Analysis of Biopsy Kidney ,  Journal of Diabetes and Metabolism. Sheng Guo1, Wubin Qian1, Fenglai Du1, Bingdi Wang1, Xiaoli Wang1, Yupeng Fang1, Xuan Chen1, Michael Benzinou1, Francine M. Gregoire2, Michael, Staup2, Keefe Chng2, Yaxiong Chen1, Yong-Fu Xiao1, Yi-Xin (Jim) Wang1,2* 1Cardiovascular and Metabolic […]

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Freshman Gains Insights in Research Stint at David H. Murdock Research Institute

  Freshman chemistry major Brandon Furr has wrapped up a four-month stint as the first UNC Charlotte intern in the In Vitro Sciences Laboratory at David H. Murdock Research Institute, having gained hands-on research experience and clarity about his future. “As I am leaving my internship, I am definitely interested in exploring research further going […]

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Experience a Dynamic Summer of Science as a P2EP Undergraduate Intern

Undergraduate students with an interest in plant research are encouraged to apply for a dynamic summer of science as part of the Plant Pathways Elucidation Project (P2EP) at the NC Research Campus in Kannapolis, a 350-acre life sciences hub dedicated to advancing scientific discoveries and development relating to human health, nutrition and agriculture. P2EP is […]

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Meet Some of the NCRC’s Leading Ladies of Science

If headlines about a shortage of women in science are to be believed, a visitor to the NC Research Campus (NCRC) in Kannapolis would expect to see very few ladies on campus. At the NCRC, women lead institutes, direct research and are part of the next generation of scientists in training on campus. Senior Research […]

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Charleata Carter Joins DHMRI as Microscopy Support Specialist

      Charleata A. Carter, PhD, joined the David H. Murdock Research Institute (DHMRI) last month as microscopy support specialist. In her new role, Carter directs DHMRI’s light microscopy facilities including confocal microscopy and biological imaging and provides consultative, collaborative scientific client support. “I have a diverse background including work in cancer research, wound […]

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The Folding of the Specific DNA Recognition Subdomain of the Sleeping Beauty Transposase Is Temperature-Dependent and Is Required for Its Binding to the Transposon DNA

The Folding of the Specific DNA Recognition Subdomain of the Sleeping Beauty Transposase Is Temperature-Dependent and Is Required for Its Binding to the Transposon DNA, PLoS One. 2014 Nov 6, Leighton GO1, Konnova TA2, Idiyatullin B3, Hurr SH1, Zuev YF3, Nesmelova IV4. The NMR experiments for this study were carried out at the David H. Murdock Research […]

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DHMRI Names John Cavanagh, PhD, as Interim President

(Kannapolis, NC- November 5, 2014) Robert Califf, MD, chief executive officer of the David H. Murdock Research Institute (DHMRI) Board of Directors, announced today that John Cavanagh, PhD, has been named interim president. “I am tremendously excited by the opportunity to take up this new role at DHMRI,” Cavanagh stated. “It is a really remarkable […]

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DHMRI Welcomes Fall Interns

 For Immediate Release         (Kannapolis, NC- October 29, 2014) The David H. Murdock Research Institute (DHMRI) on the NC Research Campus in Kannapolis welcomed four high school and college interns this fall who are working in laboratories and administration. UNC Charlotte freshman Brandon Furr is the first intern in the In Vitro […]

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Crown Bioscience Service Center Opening at DHMRI

For Immediate Release     Kannapolis, NC- The David H. Murdock Research Institute (DHMRI) at the NC Research Campus and Crown Bioscience, Inc., a leading global drug discovery and development service company headquartered in Santa Clara, CA, announce the opening of the Crown Bioscience US Research Center. The new center will open later this year […]

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David H. Murdock Announces $15 Million Annual Endowment to DHMRI

For Immediate Release (Kannapolis, NC- September 30, 2014) David H. Murdock, owner and Chairman of Dole Food Company and builder and founder of the North Carolina Research Campus (NCRC), announced today that he is committing a $15 million annual endowment in perpetuity to the David H. Murdock Research Institute (DHMRI). DHMRI is located on the […]

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David H. Murdock Announces Endowment for DHMRI

For Immediate Release (Kannapolis, NC- September 30, 2014) David H. Murdock, founder of the NC Research Campus, chairman, CEO and owner of Castle & Cooke, Inc. and owner of Dole Food Company, Inc., is holding a press conference today at 10 am at the David H. Murdock Research Institute (DHMRI), 150 Research Campus Drive, Kannapolis, […]

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David H. Murdock to Announce Gift in Perpetuity to DHMRI

Media Advisory Contact: Phyllis Beaver Marketing Director NC Research Campus pbeaver@ncresearchcampus.net 704-791-9302 David H. Murdock to Announce Gift in Perpetuity to DHMRI When: Tuesday, September 30, 2014, 10 am (ET) Where: David H. Murdock Core Laboratory Building on the NC Research Campus, 150 Research Campus Drive, in the first floor event room. Who: Mr. David […]

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MS research launched at Research Campus

KANNAPOLIS, N.C. – A North Carolina Research Campus institute has launched dedicated multiple sclerosis research with its recent hire of a postdoctoral fellow to help study the disease from a genetic perspective. Sabrina Cote, Ph.D., joined the David H. Murdock Research Institute (DHMRI) as a postdoctoral research fellow working for Simon Gregory, Ph.D., director of […]

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NC Research Campus Scientists Create Gold Standard for Measuring Oxidative Stress

By Lukas Johnson Charlotte Observer View the original article. – COURTESY OF DAVID NIEMAN A team of scientists at the North Carolina Research Campus in Kannapolis have developed what they believe could become the new global standard for measuring free radicals in athletes. Test subjects included several high-performing athletes who rode bicycles on a computerized, […]

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One of America’s Oldest Billionaires is into Health and Nutrition. Where will his fortune go?

By: Alyssa Ochs Inside Philanthropy Link to original article With a net worth of $2.4 billion, 91-year-old David H. Murdock has made some huge contributions to the fields of medical research and higher education. Murdock is owner and chairman of the Dole Food Company, located in Westlake Village California, and he’s the owner and CEO […]

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Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Molecular Biosystems

Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Molecular Biosystems.  July 2014. Baxter SS, Dibble CF, Byrd WC, Carlson J, Mack CR, Saldarriaga I, Bencharit S. David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA. David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA. Abstract Three genetic mutations […]

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Distinguishing Vaccinium Species by Chemical Fingerprinting Based on NMR Spectra, Validated with Spectra Collected in Different Laboratories

Distinguishing Vaccinium Species by Chemical Fingerprinting Based on NMR Spectra, Validated with Spectra Collected in Different Laboratories. Planta Medica. June 2014. Epub Jun 25, 2014.  Markus MA1, Ferrier J2, Luchsinger SM1, Yuk J1, Cuerrier A3, Balick MJ4, Hicks JM1, Killday KB1, Kirby CW5, Berrue F6, Kerr RG6, Knagge K7, Gödecke T8,Ramirez BE8, Lankin DC8, Pauli GF8, Burton I9, Karakach TK9, Arnason JT2, Colson KL1. 1Bruker BioSpin Corporation, Billerica, MA, USA.; 2University of Ottawa, Ottawa, […]

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Business-to-Science Partnerships Drive P2EP

June 2014  As written for Opportunities, a quarterly newsletter of the NC Research Campus covering real estate to research. Subscribe. Growth at the NC Research Campus is not all about bricks and mortar. A $1.9 million investment in the Plant Pathways Elucidation Project (P2EP) is boosting the campus’ collaborative approach to research, revealing new findings […]

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Unraveling Genomic Complexity at a Quantitative Disease Resistance Locus in Maize

Unraveling Genomic Complexity at a Quantitative Disease Resistance Locus in Maize Jun 19,2014 Tiffany M. Jamann1, Jesse A. Poland2, Judith M. Kolkman1,Laurie G. Smith3 and Rebecca J. Nelson1,* –Author Affiliations  Cornell University; 2 Kansas State University; 3 University of California, San Diego Abstract Multiple disease resistance has important implications for plant fitness, given the selection pressure that many pathogens exert directly on natural plant populations […]

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Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis

Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis. Molecular Biosystem. June 11, 2014.  Warren C Byrd,  Sarah Schwartz Baxter,  James Carlson,  Silvana Barros,  Steven Offenbacher and Sompop Bencharit. 1Department of Prosthodontics, School of Dentistry, Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; 2David H. Murdock […]

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Reduction in CD4 Central Memory T-cell subset in Co-Stimulation Modulator Abatacept-Treated Patients with Recent-Onset Type 1 Diabetes is Associated with Slower C-Peptide Decline

Reduction in CD4 Central Memory T-cell subset in Co-Stimulation Modulator Abatacept-Treated Patients with Recent-Onset Type 1 Diabetes is Associated with Slower C-Peptide Decline. Diabetes. May 16, 2014. [Epub ahead of print] Orban T1, Beam CA2, Xu P2, Moore K3, Jiang Q3, Deng J3, Muller S2, Gottlieb P4, Spain L5, Peakman M6; The Type 1 Diabetes TrialNet Abatacept Study Group. 1Joslin Diabetes Center, Boston, MA; 2Division of […]

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Murdock Institute intern named A.L. Brown intern of the year

  KANNAPOLIS — A.L. Brown High School senior Jorge Barrios was awarded Intern of the Year at an award ceremony held at the school Tuesday. He was recognized for his fall 2013 internship at the David H. Murdock Research Institute at the N.C. Research Campus. Barrios scanned accounting documents and entered them into a new […]

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NCRC team discovers new biomarker for oxidative stress

Posted: Wednesday, May 14, 2014 5:23 pm Read the original article as posted by the Independent Tribune staff KANNAPOLIS, N.C. — Scientists at the North Carolina Research Campus (NCRC) have discovered a new way to detect oxidative stress generated during exercise. A team led by Dr. David Nieman, director of the Appalachian State University Human Performance Laboratory […]

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NCRC team discovers new biomarker for oxidative stress

KANNAPOLIS, N.C. — Scientists at the North Carolina Research Campus (NCRC) have discovered a new way to detect oxidative stress generated during exercise. A team led by Dr. David Nieman, director of the Appalachian State University Human Performance Laboratory at NCRC, identified 13-HODE + 9-HODE as an oxidative stress biomarker for studies involving intense exercise, […]

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DHMRI Intern Awarded AL Brown High School “Intern of the Year”

For Immediate Release   Phyllis Beaver Marketing Director NC Research Campus pbeaver@ncresearchcampus.net www.ncresearchcampus.net   (NC Research Campus, Kannapolis, NC. May 8, 2014)- AL Brown High School senior Jorge Barrios was awarded Intern of the Year at an award ceremony held at the school on Tuesday, May 6. He was recognized for his fall 2013 internship […]

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Local businesses, and NCRC form business to science partnerships

  Link to original article in Business Today There are signs of growth at the NC Research Campus (NCRC). Site development for the new DataChambers regional data center is underway at Loop Road and Biotechnology Lane. The second suite of ready-to-go laboratories in the David H. Murdock Core Laboratory Building is finished and leasing. The […]

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Duke Energy Foundation Grants $150K to P2EP, Industry-led STEM Program

For Immediate Release           Duke Energy Foundation Grants $150K to P2EP, Industry-led STEM Program (NC Research Campus, Kannapolis, NC- May 5, 2014) The Duke Energy Foundation has renewed their support of the NC Research Campus-based, Plant Pathways Elucidation Project (P2EP) with a contribution of $150,000. Last year, the Duke Energy Foundation […]

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Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis.

Mol Biosyst. 2014 Apr 25. [Epub ahead of print] Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Baxter SS1, Dibble CF, Byrd WC, Carlson J, Mack CR, Saldarriaga I, Bencharit S. Abstract Three genetic mutations were found to cause cerebral cavernous malformation (CCM), a vascular anomaly predisposing affected individuals to […]

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Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis.

Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Molecular Biosystems. Apr 25,2014. [Epub ahead of print] Baxter SS1, Dibble CF, Byrd WC, Carlson J, Mack CR, Saldarriaga I, Bencharit S. 1David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA. Abstract Three genetic mutations were found to cause cerebral cavernous malformation (CCM), a vascular anomaly […]

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Research Night at the Kannapolis Research Campus

Details May 12, 2014 6:00 PM EST – 8:00 PM EST NC Research Campus at Kannapolis 150 Research Campus Drive Kannapolis, NC 28081 See Map Join us on Monday, May 12th from 6:30 – 8:00 pm for Research Night at the Kannapolis Research Campus!  Dr. Simon Gregory will give an Update on the Murdock Study Cohort. The […]

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Sulforaphane attenuates inflammation by decreasing Toll-like receptor 2 and 4 expression and activity in human monocytes and peripheral blood mononuclear cells

Sulforaphane attenuates inflammation by decreasing Toll-like receptor 2 and 4 expression and activity in human monocytes and peripheral blood mononuclear cells. FASEB Journal. Jonathan Mein4, Fu-Zhang Wang2, Qi Jiang2, Don James3, Sekhar Boddupalli3; Sridevi Devaraj1,5 1Baylor College of Medicine Houston TX United States; 2David H. Murdock Research Institute Kannapolis NC United States; 3Monsanto Company Woodland CA United States; […]

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Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In Vitro

Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In Vitro. PlosOne, April 1, 2014. Helena Morales Johansson, Donna R. Newman, Philip L. Sannes. Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United […]

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Ready-to-Go Lab Leased, Second in Planning

Published in Opportunities, a quarterly real estate to research newsletter of the NC Research Campus March 31, 2013 In November 2012, officials at the NCRC announced the construction of ready-to-go laboratory space in the David H. Murdock Core Laboratory Building. Four months later, the 1,500-square-foot space is fully leased. A second ready-to-go laboratory is in the […]

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Patterns of simple sequence repeats in cultivated blueberries (Vaccinium sectionCyanococcus spp.) and their use in revealing genetic diversity and population structure

Patterns of simple sequence repeats in cultivated blueberries (Vaccinium sectionCyanococcus spp.) and their use in revealing genetic diversity and population structure. Molecular Breeding. March 2014. Yang Bian, James Ballington, Archana Raja, Cory Brouwer, Robert Reid, Mark Burke, Xinguo Wang, Lisa J. Rowland, Nahla Bassil,  Allan Brown 1. Department of Horticultural Science, North Carolina State University, 2721 Founders Dr., Raleigh, NC, 27695, USA; 2. Plants for Human […]

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A Growing Campus

By Clyde Higgs, Vice President of Business Development Published in Opportunities, a quarterly real estate to research newsletter of the NC Research Campus March 14, 2014 I want to make sure everyone close to the campus is just as aware of how our momentum is building and the campus is growing: Jobs: Close to 1,000 jobs […]

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Annual Catalyst Research Symposium April 15

NCRC News The Catalyst group fosters personal and professional relationships between researchers at the NCRC, specifically helping postdoctoral researchers with professional development. As part of their mission, they host an annual research symposium. The 2014 Catalyst Research Sumposium is Tuesday, April 15 from 11:30 am to 5 pm at the NC Research Campus in the […]

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City of Kannapolis Municipal Center & Police Headquarters

Kannapolis City Council will break ground on a new 100,000 square foot municipal center and police headquarters on Tuesday, Oct. 29 at 10 a.m. The building will be located at 401 Laureate Way on approximately 6.6 acres of land donated by North Carolina Research Campus founder David H. Murdock. The site faces the David H. […]

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Infants to Teens Impacted by Genetics, Nutrition and Exercise

NCRC News Scientists at the NC Research Campus are exploring areas of genetics, nutrition and human performance that impact brain development, risk factors for disease and the overall health of infants, toddlers, young children and teenagers.   Omega-3 Intake Linked to Higher Cognition in Infants, Toddlers and Young Children Carol L. Cheatham, PhD, developmental cognitive […]

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Duke Study on Autism Risk Factor

Simon Gregory, PhD, associate professor in the section of Medical Genetics, Department of Medicine at Duke University, is part of a study published August 12, 2013 in the Journal of the American Medical Association (JAMA) Pediatrics that found a connection between induced labor and incidence of autism. Gregory is also director of the David H. Murdock Research Institute genetics facility and a […]

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NCRC internships give students a supporting role in creation of knowledge database

Salisbury Post Wayne Hinshaw / for the salisbury postCatawba College student interns at the North Carolina Research Campus work in the General Mills lab studying oats. They are Amber Williamson and Christian Krzykwa. Five Catawba College students spent their summer interning at the North Carolina Research Campus (NCRC) in Kannapolis helping to gather and organize […]

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NCRC getting personal about heart disease

  Link to original article in Business Today One of the responsibilities of running a business is finding affordable employee health coverage. NC Research Campus scientists are not going to reshape health care policy, but they are contributing to the next generation of personalized medicine that will lower healthcare costs for everyone. According to the […]

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Dole Foods, Dole Berry partner for berry health symposium

The Packer 07/26/2013 02:47:00 PM Melissa Shipman Dole Food Co., with The Dole Berry Co. LLC, Salinas, Calif., hosted the International Berry Health Benefits Symposium from June 18-20, in Charlotte, N.C., according to a news release. The event featured presentations from scientists on berries’ positive effects on disease prevention. Keith Mixon, president of Dole Berry […]

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Researchers seek to understand plants’ pathways to better health

The Packer 7/24/2013 11:47:00 AM Coral Beach A new program at the North Carolina Research Campus in Kannapolis that is funded by industry and academia promises to train tomorrow’s scientists while finding how to grow more healthful fruits and vegetables. Dubbed the Plant Pathways Elucidation Project (P2EP), the program kicks off this summer with $1.5 […]

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N.C. program immerses students in science

AG Professional North Carolina Research Campus  |  Updated: 07/18/2013 An unprecedented partnership of academic and industry organizations at the North Carolina Research Campus has launched a groundbreaking $1.5 million program to engage college students from across the state in a first-of-its-kind education and research endeavor. Called the Plant Pathways Elucidation Project (P2EP), the program teams up university […]

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Strawberry breeding program receives national sustainability initiative grants

Fresh Plaza Dr. Jeremy Pattison, strawberry breeder and geneticist with the N.C. State University Plants for Human Health Institute at the N.C. Research Campus, recently was awarded a $158,391 grant from the National Strawberry Sustainability Initiative, and is a co-investigator on a second grant in the amount of $127,168, led by Dr. Brian Whipker, also […]

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DHMRI’s $50 Million Gift

May 8, David H. Murdock, the founder and visionary behind the David H. Murdock Research Institute (DHMRI) and the NC Research Campus, announced a gift of $50 million to the DHMRI. The gift provides operational support over the next eight years.  The DHMRI is the NC Research Campus’ central laboratory that houses a staff of […]

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North Carolina emerging as world-class research hub

The Produce News by: Chip Carter   Agriculture continues to grow and is an ever-increasing part of North Carolina’s economy, a new study shows. Meanwhile, South Carolina peach producers are preparing for a bountiful and perfectly timed summer crop that should hit its peak in July, along with domestic top 10 production of greens, tomatoes […]

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David H. Murdock Research Institute Receives $50 Million Gift from David H. Murdock

The North Carolina Research Campus For Immediate Release  Contact: Phyllis Beaver Marketing Director NC Research Campus pbeaver@ncresearchcampus.net www.ncresearchcampus.net (Durham, NC- May 8, 2013)-  David H. Murdock, the founder and visionary behind the David H. Murdock Research Institute (DHMRI) located at the North Carolina Research Campus (NCRC) in Kannapolis, announced a gift of $50 million to […]

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Davidson, Lenoir-Rhyne Students Involved in Cutting-Edge Blueberry Genome Research

PHHI KANNAPOLIS, NC – Cutting-edge research on sequencing the blueberry genome will be incorporated into college curriculum at Davidson College and Lenoir-Rhyne University, in cooperation with N.C. State University at the N.C. Research Campus. Students will be involved in identifying specific genes that can be used to produce plants with desired characteristics, as well as […]

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Increasing Lutein Levels in Broccoli to Fight Age-Related Eye Problems

PHHI Dr. Allan Brown uses conventional plant breeding methods to enhance lutein levels and other helpful compounds in broccoli. KANNAPOLIS, NC – A new N.C. State University study under way at the Plants for Human Health Institute at the N.C. Research Campus is focused on enhanced levels of lutein in broccoli. Lutein, an antioxidant, is […]

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Increasing Lutein Levels in Broccoli to Fight Age-Related Eye Problems

Plants for Human Health Institute KANNAPOLIS, NC – A new N.C. State University study under way at the Plants for Human Health Institute at the N.C. Research Campus is focused on enhanced levels of lutein in broccoli. Lutein, an antioxidant, is also found in leafy greens such as kale and spinach. Lutein is associated with […]

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New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering.

New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering.  Archives of Virology. March 13, 2013. Martin SL, He L, Meilleur F, Guenther RH, Sit TL, Lommel SA (Plants for Human Health Institute and DHMRI, NC Research Campus) and D, Heller WT. […]

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Klebsiella Linked to Infant Melamine Deaths

The UNC Greensboro Center for Translational Biomedical Research and the David H. Murdock Research Institute in partnership with scientists from Shanghai Jiao Tong University in Shanghai, China and the Imperial College of London, United Kingdom have shed light on why so many babies who drank melamine-tainted milk in 2008 did not die. The bacteria Klebsiella terrigena […]

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Rowan-Cabarrus Biotech Graduates Advancing Scientific Discovery

              (NC Research Campus, Kannapolis, NC- February 18, 2013)- Behind every great scientist is a great research assistant. At the North Carolina Research Campus (NCRC) in Kannapolis those great research assistants and research technicians are most often graduates of Rowan-Cabarrus Community College’s two-year applied science associate degree program in biotechnology. Graduates are working […]

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Melamine-induced renal toxicity is mediated by the gut microbiota

Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. February 13, 2013. Zheng X,Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Luther M, Su M, Nicholson JK, Jia W. Shanghai Key Laboratory of Diabestes Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated […]

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Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics

Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics. Advanced Healthcare Materials. January 20, 2013. Honarbakhsh S, Guenther RH, Willoughby JA, Lommel SA (Plants for Human Health Institute and DHMRI, NC Research Campus), Pourdeyhimi B.  The Nonwovens Institute, North Carolina State University, 2401 Research Drive, Raleigh, North Carolina, 27695 USA. Abstract Therapeutic polylactide […]

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The heterodimerization of platelet-derived chemokines

The heterodimerization of platelet-derived chemokines. Biochimica et Biophysica Acta (BBA)- Proteins and Proteomics. January 2013. James Carlson, Sarah A. Baxter, Didier Dréau, Irina V. Nesmelova. Analytical Sciences Laboratory, David H. Murdock Research Institute and the Department of Biology,  Department of Physics and Optical Science and the Center for Biomedical Engineering and Science, University of North […]

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Ready-To-Go Lab Space Available

Published in Opportunities, a quarterly real estate to research newsletter of the NC Research Campus November 30, 2012 Construction is starting on ready-to-go lab space that will be available in February 2013. The 1,500-square-foot wet laboratory is the first pre-built, flexible lab space to be constructed at the NCRC since the campus opened four years ago. […]

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Day five on the Dean’s tour: Kannapolis, Charlotte and Winston-Salem

WHEN: November 7, 2012 WHERE: North Carolina Research Campus “You have to see it to believe it.” So said new College of Agriculture and Life Sciences dean Richard Linton on the fifth leg of his statewide tour, of the North Carolina Research Campus in Kannapolis. “I’ve seen photos online and even watched a video tour, […]

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Elucidating role of salivary proteins in denture stomatitis using a proteomic approach.

Elucidating role of salivary proteins in denture stomatitis using a proteomic approach. Mol Biosyst. 2012 Oct 30, Bencharit S1, Altarawneh SK, Baxter SS, Carlson J, Ross GF, Border MB, Mack CR, Byrd WC, Dibble CF, Barros S, Loewy Z, Offenbacher S. 1Department of Prosthodontics, School of Dentistry, University of North Carolina, CB#7450, Chapel Hill, NC 27599, USA. Sompop_Bencharit@dentistry.unc.edu […]

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NCRC Focus of UNC Charlotte Life Sciences Conference

Contact: Phyllis Beaver Marketing Director North Carolina Research Campus pbeaver@ncresearchcampus.net www.ncresearchcampus.net   (NC Research Campus, Kannapolis, NC- October 23, 2012)- The North Carolina Research Campus in Kannapolis, a 350-acre life science research center just north of Charlotte, is the focus of the eleventh annual UNC Charlotte Life Sciences Conference. The conference is being held on […]

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The Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) Study Community Registry and Biorepository.

The Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) Study Community Registry and Biorepository.  October 2012. American Journal of Translational Research. Bhattacharya S, Dunham AA, Cornish MA, Christian VA, Ginsburg GS, Tenenbaum JD, Nahm ML, Miranda ML, Califf RM, Dolor RJ, Newby LK. Duke Translational Research Institute/MURDOCK Study. Abstract Current understanding of chronic diseases […]

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RTI International receives NIH contract to serve as regional metabolomics research core center

RTI International has been awarded a five-year contract from the National Institutes of Health to serve as a regional comprehensive metabolomics research core center. This center, funded by the NIH Common Fund, is intended to increase the national capacity for metabolomics services to basic, translational and clinical investigators. Metabolomics, the study of metabolites and biochemical […]

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Murdoch Institute will get funding for genome group

KANNAPOLIS – The David H. Murdock Research Institute (DHMRI) announced today that it will receive funding from the North Carolina Biotechnology Center to sponsor the Genomic Sciences Regional Exchange Group (Gene REG) which is designed to focus on genomics-based research. Gene REG will serve as a forum for discussing scientific ideas, new directions and data […]

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DHMRI to Provide Metabolomics Services to RTI International

Contact: Benjamin Machon Business Development bmachon@dhmri.org 704-250-2648 DHMRI to Provide Metabolomics Services to RTI International’s Regional Comprehensive Metabolomics Research Core Center (North Carolina Research Campus, Kannapolis, NC- September 24, 2012)– The David H. Murdock Research Institute (DHMRI) at the North Carolina Research Campus will provide scientific expertise and state-of-the-art equipment access to the Regional Comprehensive […]

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The heterodimerization of platelet-derived chemokines

The heterodimerization of platelet-derived chemokines. Biochemica et Biophysica acta. September 2012. Carlson J, Baxter SA, Dréau D, Nesmelova IV. Analytical Sciences Laboratory, David H. Murdock Research Institute. Abstract Chemokines encompass a large family of proteins that act as chemoattractants and are involved in many biological processes. In particular, chemokines guide the migration of leukocytes during […]

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Murdock Research Institute adds microscopy scientist

The David H. Murdock Research Institute (DHMRI) has a new member, Anita McCauley, PhD. She will oversee the light microscopy facilities, offering consultative, collaborative scientific client support on a part-time basis. She will also lead workshops to further enhance knowledge of the microscopy capabilities available at DHMRI. McCauley comes to DHMRI with over 13 years […]

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Murdock Research Institute adds microscopy scientist

The David H. Murdock Research Institute (DHMRI) has a new member, Anita McCauley, PhD. She will oversee the light microscopy facilities, offering consultative, collaborative scientific client support on a part-time basis. She will also lead workshops to further enhance knowledge of the microscopy capabilities available at DHMRI. McCauley comes to DHMRI with over 13 years […]

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Monsanto Genetic ‘X-Ray Glasses’ Speed Tastier Tomatoes

By Jack Kaskey, Bloomberg News Link to article A tomato breeder displays varieties grown at the Monsanto Co. facility in Woodland, California. Photographer: Noah Berger/Bloomberg Doug Heath, a tomato breeder for Monsanto Co. (MON:US), offers visitors juicy slices of Cherokee Purple, a delicate variety with a sweetness and acidity he’s trying to replicate in hardier […]

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NCRC’s Murdock institute taps interim business development director

By: Jennifer Thomas, Charlotte Business Journal Benjamin Machon has been named interim director of business development for the David H. Murdock Research Institute. That nonprofit research institute is part of the N.C. Research Campus in Kannapolis. That 350-acre life-sciences hub focuses on health, nutrition and agriculture. Machon replaces Mike Luther, who has taken a position […]

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DHMRI Advances Personalized Medicine in North Carolina

Personalized medicine is transforming healthcare by precipitating a shift to a model that takes into account individual differences and the influence of genetics and the environment. The advantage is more effective treatments, an enhanced ability to predict risk for chronic disease and the opportunity for earlier medical intervention. The David H. Murdock Research Institute (DHMRI) is […]

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Collaboration will provide testing for botanical purity

  The Salisbury Post KANNAPOLIS — The David H. Murdock Research Institute and Bent Creek Institute Inc., an affiliate of the North Carolina Arboretum, today announced a collaboration to provide purity and compositional testing services for the botanical natural products industry. The new nonprofit, dubbed the U.S. Botanical Safety Laboratory, will combine the expertise and […]

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Bent Creek Institute and DHMRI Join Forces

    Kannapolis, N.C., May 2, 2012-The David H. Murdock Research Institute (DHMRI) and Bent Creek Institute, Inc., an affiliate of The North Carolina Arboretum, announced the signing of an ongoing collaboration to provide purity and compositional testing services to supply chain stakeholders in the botanical natural products industry. This multi-laboratory non-profit collaborative in North […]

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Urine metabolite profiling offers potential early diagnosis of oral cancer

Urine metabolite profiling offers potential early diagnosis of oral cancer Metabolomics, April 2012, Guo X. Xie, Tian L. Chen, Yun P. Qiu, Peng Shi, Xiao J. Zheng, Ming M. Su, Ai H. Zhao, Zeng T. Zhou, Wei Jia Abstract Oral cancer is the sixth most common human cancer, with a high morbidity rate and an overall 5-year survival rate of less than 50%. It is often […]

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An alternative paradigm for the role of antimalarial plants in Africa.

An alternative paradigm for the role of antimalarial plants in Africa. Scientific World Journal. April 2012. Maranz S. David H. Murdock Research Institute. Abstract Most investigations into the antimalarial activity of African plants are centered on finding an indigenous equivalent to artemisinin, the compound from which current frontline antimalarial drugs are synthesized. As a consequence, […]

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Exploring salivary proteomes in edentulous patients with type 2 diabetes

Exploring salivary proteomes in edentulous patients with type 2 diabetes. Mol Biosyst. April 2012, Border MB, Schwartz S, Carlson J, Dibble CF, Kohltfarber H, Offenbacher S, Buse JB, Bencharit S. Molecular Biosystems. David H. Murdock Research Institute. Abstract Type 2 diabetes and tooth loss are linked both epidemiologically and pathophysiologically. We applied label-free differential protein expression analysis […]

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Monday and Tuesday Events Feature NCRC Scientists

NCRC Monday, April 16 and Tuesday, April 17, the Live and Learn Film Series and State of the Studies at the NC Research Campus are free events that provide opportunities for people to talk with scientists and learn about the research and clinical studies that are underway on campus. (NC Research Campus, Kannapolis, NC- April […]

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Spring Into Science through Events at NCRC and in Kannapolis April 2012 Events

NCRC Spring into Science at NCRC (NC Research Campus, Kannapolis, NC- April 4, 2012)- April marks a record setting number of science-oriented events at the NC Research Campus (NCRC) and in Kannapolis that are free and for families. Live and Learn Film Series A free showing of the movie Living Proof will be held on April […]

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USBSL Tests Botanical ID, PurityUSBSL Tests Botanical ID, Purity

Natural Products Insider ASHEVILLE, N.C.–The nonprofit US Botanical Safety Laboratory (USBSL) will begin offering botanical identity, purity and phytochemical composition testing of botanical ingredients starting April 23, 2012. The organization, formed by the Bent Creek Institute and The North Carolina Arboretum, will offer the “Purity” tests including assays for microbials, heavy metals and pesticides. USBSL will serve […]

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Human gouty arthritis is associated with a distinct serum trace elemental profile

Human gouty arthritis is associated with a distinct serum trace elemental profile. Metallomics, March 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for Research Excellence in BioActive Food Components and David H. Murdock Research Institute. Abstract Homeostatic imbalance of essential trace elements […]

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Distinct urinary metabolic profile of human colorectal cancer.

Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3, Cheng Y1, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W. Department of Chemistry, East China Normal University, Shanghai 200062, China. Abstract A full spectrum […]

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Learn and Live film series Feb. 20: ‘Food Stamped’

Salisbury Post KANNAPOLIS —The North Carolina Research Campus announces the continuation of the Learn and Live Film Series in 2012 with showings of “Food Stamped” on Feb. 20 and “Living Proof” on April 16. Both movies are free and will be shown at 7 pm in the events room of the David H. Murdock Research […]

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Food Stamped and Living Proof Headline the 2012 Lean and Live Film Series

NCRC The North Carolina Research Campus announces the continuation of the Learn and Live Film Series in 2012 with showings of Food Stamped on February 20 and Living Proof on April 16. (NC Research Campus, Kannapolis, NC- January X, 2012)- The North Carolina Research Campus (NCRC) in Kannapolis continues the Learn and Live Film Series in […]

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Urinary metabolite markers of precocious puberty

Urinary metabolite markers of precocious puberty Mol Cell Proteomics. 2012 Jan;11, Qi Y1, Li P, Zhang Y, Cui L, Guo Z, Xie G, Su M, Li X, Zheng X, Qiu Y, Liu Y, Zhao A, Jia W, Jia W. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Abstract The incidence of precocious puberty (PP, the appearance of […]

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Chinese New Year celebration in Kannapolis Jan. 14

Salisbury Post KANNAPOLIS — Scientists at the N.C. Research Campus in Kannapolis who formed the Cabarrus Chinese American Association will host a Chinese New Year celebration Jan. 14 to raise money for a Chinese Language and Art School. The festival will run from 1 to 6 p.m. at Cox Mill High School, 1355 Cox Mill […]

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NCRC Scientists Open A Window To Chinese Culture

Scientists at the North Carolina Research Campus in Kannapolis formed the Cabarrus Chinese American Association and are hosting a Chinese New Year celebration on January 14, 2012 to raise money for their Chinese Language and Art School. In American culture, January is usually a quiet month to recover from the revelry of Thanksgiving, Christmas and […]

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Protein Modification by Deamidation Indicates Variations in Joint Extracellular Martrix Turnover.

Catterall JB, Hsueh MF, Stabler TV, Feng S, McCudden CF, Bolognesi M, Zuru R, Jordan JM, Renner JB, Kraus VB. Protein Modification by Deamidation Indicates Variations in Joint Extracellular Martrix Turnover. JBiolChem.2012 Feb 10;287(7):4640-51. Epub 2011 Dec 16. Abstract As extracellular proteins age, they undergo and accumulate nonenzymatic post-translational modifications that cannot be repaired. We […]

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Mannan structural complexity is decreased when Candida albicans is cultivated in blood or serum at physiological temperature.

Mannan structural complexity is decreased when Candida albicans is cultivated in blood or serum at physiological temperature. Lowman DW1, Ensley HE, Greene RR, Knagge KJ, Williams DL, Kruppa MD Abstract The Candida albicans cell wall provides an architecture that allows for the organism to survive environmental stress as well as interaction with host tissues. Previous […]

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Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice

Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice Hongfei Xia, Yi Chi, Xin Qi, Mingming Su, Yu Cao, Peipei Song, Xin Li, Tianlu Chen, Aihua Zhao, Yinan Zhang Abstract Di-n-butyl phthalate (DBP) has been linked to the neural, reproductive and developmental toxicity. We present here a metabolomic study that characterized the metabolic variations associated with the DBP-induced teratogenesis in maternal and fetal mice. DBP […]

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Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action.

Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. Xuan J1, Pan G, Qiu Y, Yang L, Su M, Liu Y, Chen J, Feng G, Fang Y, Jia W, Xing Q, He L. Abstract Despite recent advances in understanding the pathophysiology of schizophrenia and the mechanisms of antipsychotic drug action, the development […]

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Metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice

Metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice Chi Y1, Xia H, Su M, Song P, Qi X, Cui Y, Cao Y, Chen T, Qiu Y, Zhao A, Ma X, Zheng X, Jia W. Abstract Recent studies have demonstrated that polybrominated diphenyl ethers (PBDEs), a group of industrial chemicals, could disrupt thyroid […]

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Use of Mutant-Assisted Gene Identification and Characterization (MAGIC) to identify novel genetic loci that modify the maize hypersensitive response.

Use of Mutant-Assisted Gene Identification and Characterization (MAGIC) to identify novel genetic loci that modify the maize hypersensitive response. Chaikam V1, Negeri A, Dhawan R, Puchaka B, Ji J, Chintamanani S, Gachomo EW, Zillmer A, Doran T, Weil C, Balint-Kurti P, Johal G. Abstract The partially dominant, autoactive maize disease resistance gene Rp1-D21 causes hypersensitive response (HR) lesions to form spontaneously on leaves and stems in […]

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Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing.

Lee EJ,Pei L,Srivastava G,Joshi T,Kushwaha G,Choi JH,Robertson KD,Wang X,Colbourne JK,Zhang L,Schroth GP, Xu D,Zhang K,Shi H.Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing. NucleicAcidsRes.2011 Oct;39(19):e127. Epub 2011 Jul 23. Abstract We applied a solution hybrid selection approach to the enrichment of CpG islands (CGIs) and promoter sequences from the human genome for […]

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Metabolic signature of pregnant women with neural tube defects in offspring.

Metabolic signature of pregnant women with neural tube defects in offspring. Zheng X1, Su M, Pei L, Zhang T, Ma X, Qiu Y, Xia H, Wang F, Zheng X, Gu X, Song X, Li X, Qi X, Chen G, Bao Y, Chen T, Chi Y, Zhao A, Jia W. Abstract Neural tube defects (NTDs) are […]

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Serum apolipoprotein C-III is independently associated with chronic hepatitis C infection and advanced fibrosis.

Rowell J, Thompson A, Guyton JR, Qian LX, McHutchison JG, McCarthy JJ and Patel K. Serum apolipoprotein C-III is independently associated with chronic hepatitis C infection and advanced fibrosis. Hepatol Int 2011 Jul 7. Abstract BACKGROUND: The hepatitis C virus (HCV) is known to disrupt lipid metabolism, making serum lipoprotein levels good candidates to explore […]

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Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride

Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride Xiaoyan Wang, Jingchao Lin, Tianlu Chen, Mingmei Zhou, Mingming Su, Wei Jia Abstract Diammonium glycyrrhizinate (DG), a constitutent of Glycyrrhiza uralensis, has a protective effect on hepatic injury, hepatisis and cirrhosis. To date, the mechanism has been poorly understood, especially at the metabolic level. A […]

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Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma.

Chen, Tianlu, Xie, Guoxiang, Wang, Xiaoying, Fan, Jia, Qiu, Yunping, Zheng, Xiaojiao, Qi, Xin, Cao, Yu, Su, Mingming, Wang, Xiaoyan, Xu, Lisa X. Yen, Yun, Liu, Ping, Jia, Wei (2011). Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma. . Molecular and Cellular Proteomics, 2011July;10(7):M110.004945. Epub 2011 Apr 25. Abstract Hepatocellular carcinoma (HCC) […]

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High Predictive Accuracy of an Unbiased Proteomic Profile for Sustained Virologic Response in Chronic Hepatitis C Patients

Patel K, Lucas J, Thompson JW, Dubois LG, Tillmann H, Thompson A, Uzarski D, Califf RM, Moseley MA, Ginsburg GS, McHutchison JG, McCarthy JJ. High Predictive Accuracy of an Unbiased Proteomic Profile for Sustained Virologic Response in Chronic Hepatitis C Patients. Hepatology 2011; 53(6):1809-18. Abstract Chronic hepatitis C (CHC) infection is a leading cause of […]

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Salivary metabolite signatures of oral cancer and leukoplakia

Wei, Jie, Xie, Guoxiang, Zhoul, Zengtong, Shi, Peng, Qiu, Yunping, Zheng, Xiaojiao, Chen, Tianlu, Su, Mingming, Zhao, Aihua, Jia, Wei (December, 2010).  Salivary metabolite signatures of oral cancer and leukoplakia. International Journal of Cancer 10.1002/ijc.25881 NA. Abstract Oral cancer, one of the six most common human cancers with an overall 5-year survival rate of <50%, is […]

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Reclassification of Cardiovascular Risk Using Integrated Clinical and Molecular Biosignatures: Design and Rationale of the MURDOCK Horizon 1 Cardiovascular Disease Study

Shah SH, Granger CB, Hauser ER, Kraus WE, Sun JL, Pieper K, Nelson CL, DeLong ER, Califf RM, Newby LK, for the MURDOCK Horizon 1 Cardiovascular Disease Investigators. Reclassification of Cardiovascular Risk Using Integrated Clinical and Molecular Biosignatures: Design and Rationale of the MURDOCK Horizon 1 Cardiovascular Disease Study. Am Heart J 2010 Sep;160(3):371-379.e2. Abstract […]

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An automated data analysis pipeline for GC-TOF-MS metabonomics studies

Jiang W,Qiu Y,Ni Y,Su M,Jia W,Du X.An automated data analysis pipeline for GC-TOF-MS metabonomics studies. Also in partnership with UNC Greensboro. Department ofBioinformatics & Genomics, University of North Carolina at Charlotte, Kannapolis, NC 28081, USA. JournalofProteomeResearch.2010 Nov 5;9(11):5974-81. Epub 2010 Sep 29. Abstract Recent technological advances have made it possible to carry out high-throughput metabonomics […]

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Simplifying informed consent for biorepositories: stakeholder perspectives.

Beskow LM, Friedman J, Hardy C, Lin L, Weinfurt KP. Simplifying informed consent for biorepositories: stakeholder perspectives. Genetics in Medicine; 2010 Aug 6. Abstract PURPOSE: Complex and sometimes controversial information must be conveyed during the consent process for participation in biorepositories, and studies suggest that consent documents in general are growing in length and complexity. […]

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Serum Proteomic Profiles Associated with IL28B Genotype among CHC Patients

McCarthy JJ, Cyr D, Lucas J, Thompson JW, Patel K, Thompson A, Tillmann H, Clark PJ, Moseley MA and McHutchison JG. Serum Proteomic Profiles Associated with IL28B Genotype among CHC Patients. Hepatology 2010 (52): 4 (suppl):727A Abstract INTRODUCTION: Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous […]

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Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection.

Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG and  McCarthy JJ.  Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection. Hepatology 2010;51(6): 1904-11.  PMID: 20235331. Abstract Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda […]

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Developing a Simplified Consent Form for Biobanking

Beskow LM, Friedman JY, Hardy NC, Lin L, Weinfurt KP (2010) Developing a Simplified Consent Form for Biobanking. PLoS ONE 5(10): e13302. doi:10.1371/journal.pone.0013302 Abstract BACKGROUND: Consent forms have lengthened over time and become harder for participants to understand. We sought to demonstrate the feasibility of creating a simplified consent form for biobanking that comprises the […]

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An optimized procedure for metabonomic analysis of rat liver tissue using gas chromatography/time-of-flight mass spectrometry

Pan, Li, Qiu, Yunping, Chen, Tianlu, Lin, Jinchao, Chi, Yi, Su, Mingming, Zhao, Aihua, Jia, Wei (2010). An optimized procedure for metabonomic analysis of rat liver tissue using gas chromatography/time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 52(4) 589-596. Abstract In this paper, we present a tissue metabonomic method with an optimized extraction procedure […]

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Urinary metabonomic study on colorectal cancer

Qiu, Yunping, Cai, Guoxiang, Su, Mingming, Chen, Tianlu, Liu, Yumin, Xu, Ye, Ni, Yan, Zhao, Aihua, Cai, Sanjun, Xu, Lisa X., Jia, Wei (2010).  Urinary metabonomic study on colorectal cancer .Journal of Proteome Research 9(3) 1627- 1634. Abstract After our serum metabonomic study of colorectal cancer (CRC) patients recently published in J. Proteome Res., we profiled […]

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Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC- QTOFMS

Qiu, Yunping, Cai, Guoxiang, Su, Mingming, Chen, Tianlu, Zheng, Xiaojiao, Xu, Ye, Ni, Yan, Zhao, Aihua, Xu, Lisa X., Cai, Sanjun, Jia, Wei (2009).  Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC- QTOFMS.  Journal of Proteome Research 8(10) 4844-4850. Abstract Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with […]

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