Cancer Prevention and Treatment Search Results

Chemopreventative Effect of Phytochemimcals against Colon Cancer

Chemopreventative Effect of Phytochemimcals against Colon Cancer, Medicinal and Aromatic Plants, December 2015. Williams LL, Khatiwada J and Davis S. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, North Carolina Research Campus, Kannapolis, NC. Editorial Currently, the incidence of colorectal cancer (CRC) has been declining, even though it remains a major public […]

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p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

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Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity

Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity, J Med Chem. 2015 J Zhu Y, Fu J, Shurlknight K, Soroka D, Hu Y, Chen XL, Sang S. Abstract Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized […]

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Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer, July 22, 2015, In Press Accepted Manuscript, Yujie Fu, Onat Kadioglu, Benjamin Wiench, Zuofu Wei, Wei Wang, Meng Luo, Xiaohe Yang, Chengbo Gu, Yuangang Zu, Thomas Efferth NC Central University <style>.requiresJS{display:none}.dartAd{display:block !important}</style> Abstract Anti-estrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established anti-hormones such as tamoxifen, novel […]

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Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib, Journal of Cancer Research, April 22, 2015, Ming Zhao, Amanda Blackwelder, Harry Lee, and Xiaohe Yang Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC. Abstract 3557: Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib Abstract […]

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Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats

Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats. Alcoholism Clinical and Experimental Research. May 21, 2014. Qiong Li1, Guoxiang Xie2, Wenliang Zhang1, Wei Zhong1, Xiuhua Sun1, Xiaobing Tan1, Xinguo Sun1, Wei Jia2,3and Zhanxiang Zhou1,4,* 1 Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina; 2 University of Hawaii Cancer Center, Honolulu, Hawaii; 3 Center for Translational […]

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Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells

Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells. Journal of Agricultural Food Chemistry. May 21, 2014; Epub 2014 May 12. Fu J1, Chen H, Soroka DN, Warin RF, Sang S. 1Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus , 500 Laureate […]

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Cabarrus Health Alliance Receives Grant Funds to Support Breast Health

Cabarrus Health Alliance Receives Grant Funds to Support Breast Health Kannapolis, N.C. – The Cabarrus Health Alliance was presented with a $15,000 check at the Board of Health meeting on February 11 to continue breast cancer prevention and treatment efforts. Focused on a Cure is the foundation of Karen Goforth, owner of Irresistible Portraits in […]

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A Model Fish

Scientists with North Carolina Central University Nutrition Research Program and NCA&T’s Center for Excellence in Post-Harvest Technologies teamed up to study the bioactive compounds in ginger. They did it using a rather model fish called zebrafish. NC Central scientist TinChung Leung, PhD, uses the model fish for research into natural compounds that can help prevent […]

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NCCU and NCA&T Cancer Research on UNC-TV

UNC TV Researchers can’t test experimental cures for diseases and possible drug therapies on humans so they use the zebrafish for initial testing. That’s because the journey from egg to embryo is the same in zebrafish and humans. The image on the computer screen in the North Carolina Central University lab at the North Carolina […]

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Ginger Shogaols: Promising Prevention for Lung and Colon Cancer

Shengmin Sang, PhD, associate professor and leadscientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies, published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most recent findings concentrate on shogaol metabolites and lung and colon cancer prevention. Shogaols are the dehydrated […]

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Heart and Liver Disease: Deciphering Metabolic and Genetic Connections

The human genetic code is 99.9 percent identical. What makes people individuals, genetically speaking, equates to .1 percent of their individual genetic make-up and accounts for thousands of differentiations at the molecular level.  Deciphering those differentiations or polymorphisms and their involvement in the development of disease is the work of scientists like Karen Corbin, PhD, RD, and […]

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Tracking Parallel Pathways of Obesity, Diabetes and Inflammation

A generation ago, the prevailing opinion was that once a person became obese they would develop type 2 diabetes. Today, scientists like Slavko Komarnytsky, PhD, assistant professor of pharmacogenomics with NC State University (NCSU) Plants for Human Health Institute (PHHI) at the NC Research Campus (NCRC), know that obesity and diabetes are related but that […]

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Collaborations Driving Ginger Research for Cancer, Anemia

Ginger is appreciated for its aromatic and tangy taste and is enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

One of the most controversial and confusing questions surrounding breast cancer is the effect of eating soy. Some studies say soy and the isoflavone genistein that it contains prevents breast cancer. Other studies say genistein is a risk factor for developing breast cancer. Breast cancer researcher Xiaohe Yang, PhD, associate professor with the North Carolina Central […]

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Zinc: A Potential Treatment for Alcohol-Induced Fatty Liver Disease

While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou is co-director of the UNC Greensboro Center forTranslational Biomedical Research and an expert on the disease. During his visit, Zhou counseled his friends on dietary changes that might help them. One day, […]

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DHMRI Advances Personalized Medicine in North Carolina

Personalized medicine is transforming healthcare by precipitating a shift to a model that takes into account individual differences and the influence of genetics and the environment. The advantage is more effective treatments, an enhanced ability to predict risk for chronic disease and the opportunity for earlier medical intervention. The David H. Murdock Research Institute (DHMRI) is […]

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Ginger: A Potential Treatment for Anemia

Ginger is a spice recognized for its tangy flavor and its many health benefits. TinChung Leung, PhD, of NC Central University and Shengmin Sang, PhD, of NC A&T State University, both scientists at the NC Research Campus, have collaborated on a series of studies using a zebrafish model that found ginger may be a treatment […]

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