BioInformatics Search Results

Homegrown Scientists Working at the NCRC

The goal of many students when they graduate from high school is to get as far away from home as possible. Some students in Concord and Kannapolis, just outside of Charlotte, are finding that the best opportunity for careers in science is right in their own backyard at the NC Research Campus. Coming Home Grant […]

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P2EP Kicks Off Third “Summer of Science” at NC Research Campus

The third class of the Plant Pathways Elucidation Project (P2EP) kicked off an 11-week summer of science at the NC Research Campus (NCRC). This year’s class will not only work in teams to research crops including broccoli, blueberries, strawberries and oats, they will also be involved in cooking demonstrations and community outreach, engaging the public with […]

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A need for a transdisciplinary environment: the Plant Pathways Elucidation Project.

A need for a transdisciplinary environment: the Plant Pathways Elucidation Project. Trends Plant Sci. 2014 Aug, Reid RW1, Brouwer CR1, Jackson EW2, Lila MA3. Department of Bioinformatics and Genomics, 150 Research Campus Drive, Suite 3333, Kannapolis, NC 28081, USA. 2General Mills, North Carolina Research Campus, Kannapolis, NC 28081, USA. 3Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC […]

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N.C. Research Campus internship program plants seeds to grow STEM careers

As published on WRAL TechWire.com By Frank Vinluan KANNAPOLIS, N.C. — Allan Brown likens his blueberry research to trying to put together one big jigsaw puzzle. Brown, an applied molecular geneticist with N.C. State University’s Plants for Human Health Institute at the N.C. Research Campus in Kannapolis, has spent several years working on the genomic sequence of the […]

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A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration.

A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration. May 15, 2014 Gruber HE1, Sha W2, Brouwer CR2, Steuerwald N3, Hoelscher GL1, Hanley EN1. Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, N.C.; 2. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, N.C.; 3. Bioinformatics Services Division, North Carolina Research Campus, Kannapolis, N.C.; 4. […]

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Comparison of Culture and Molecular Techniques for Microbial Community Characterization in Infected Necrotizing Pancreatitis

Comparison of Culture and Molecular Techniques for Microbial Community Characterization in Infected Necrotizing Pancreatitis. Journal of Surgical Research. May 9, 2014. Erin M. Hanna, MD1, Timothy J. Hamp, MS2, Iain H. McKillop, PhD1,Farah Bahrani-Mougeot,PhD3, John B. Martinie, MD1, James M. Horton, MD4, David Sindram, MD, PhD1, Raad Z. Gharaibeh,PhD2, 5, Anthony A. Fodor, PhD2, David A. Iannitti, MD1 1Department of Surgery, Carolinas Medical Center, Charlotte, NC; 2Department of Bioinformatics and Genomics, UNC […]

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Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists

Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists.  Applied Physiology, Nutrition and Metabolism. March 2014. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson D, Sha W, Meaney MP. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus; Dole Nutrition Research Laboratory, NC Research Campus; UNC Charlotte Bioinformatics Services Division, […]

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Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice.

Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice. American Journal of Physiology. Gatrointestinal and liver physiology. December 2013. [Epub Oct 10, 2013]. Sun X, Luo W, Tan X, Li Q, Zhao Y, Zhong W, Sun X, Brouwer C, Zhou Z. Center for Translational & Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis. Abstract […]

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Peanut Skin Polyphenols Lower Lipid Levels, Reduce Fat

For Immediate Release Phyllis Beaver Marketing Director NC Research Campus pbeaver@ncresearchcampus.net   Laurie Gengenbach NCA&T Communications lagengen@ncat.edu View the full story.   (NC Research Campus, Kannapolis, NC- December 3, 2013) Scientists with North Carolina Agricultural and Technical State University’s Center for Excellence in Post-Harvest Technologies at the NC Research Campus in Kannapolis have discovered in […]

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A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.

A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutrition Journal. November 25, 2013. David C Nieman, R Andrew Shanely, Beibei Luo, Dustin Dew, Mary Pat Meaney, and Wei Sha. Appalachian State University, Human Performance Lab, North Carolina Research Campus; Key Laboratory of Exercise and Health Sciences of Ministry […]

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UNC Charlotte Bioinformatics Expanding NCRC Offices

Published in Opportunities, a real estate to research quarterly newsletter of the NC Research Campus September 30, 2013 UNC Charlotte is expanding their 3,000 square-foot office space in the David H. Murdock Research Institute core laboratory with a 1,200-square-foot addition. “We’re looking to expand and add space that is more flexible to set-up cubicles and have […]

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UNC Charlotte Bioinformatics Plans Expansion of NCRC Offices

    Cory Brouwer, PhD, director of the UNC Charlotte Bioinformatics Research Services Division at the NC Research Campus (NCRC), directs projects involving complex biological computations and the management of immense data sets. This fall, he has simple addition at the forefront of his mind. In October, all of the details should be squared away […]

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The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide

The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide. PLoS One.  September 20, 2013. Sha W, Martins AM, Laubenbacher R, Mendes P, Shulaev V. Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia; Bioinformatics Research Division, University of North Carolina at Charlotte, Kannapolis, NC. Abstract Oxidative stress is a well-known biological process that occurs in all […]

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Duke Study on Autism Risk Factor

Simon Gregory, PhD, associate professor in the section of Medical Genetics, Department of Medicine at Duke University, is part of a study published August 12, 2013 in the Journal of the American Medical Association (JAMA) Pediatrics that found a connection between induced labor and incidence of autism. Gregory is also director of the David H. Murdock Research Institute genetics facility and a […]

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P2EP: The Dynamics of New Biology

By Pete Prunkl, Greater Charlotte Biz, Tuesday, April 1, 2013 Under the header of “Not Your Father’s Biology,” the National Research Council (NRC) issued a report entitled A New Biology for the 21st Century. In it, the writers coined the term “New Biology” to describe the dynamic needed for the life sciences to address some of […]

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Researchers seek to understand plants’ pathways to better health

The Packer 7/24/2013 11:47:00 AM Coral Beach A new program at the North Carolina Research Campus in Kannapolis that is funded by industry and academia promises to train tomorrow’s scientists while finding how to grow more healthful fruits and vegetables. Dubbed the Plant Pathways Elucidation Project (P2EP), the program kicks off this summer with $1.5 […]

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N.C. program immerses students in science

AG Professional North Carolina Research Campus  |  Updated: 07/18/2013 An unprecedented partnership of academic and industry organizations at the North Carolina Research Campus has launched a groundbreaking $1.5 million program to engage college students from across the state in a first-of-its-kind education and research endeavor. Called the Plant Pathways Elucidation Project (P2EP), the program teams up university […]

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UNC Charlotte part of $1.5 million N.C. Research Campus project

  UNC Charlotte News July 17, 2013 An unprecedented partnership of academic and industry organizations at the North Carolina Research Campus is launching a $1.5 million program to engage college students from across the state in a first-of-its-kind education and research endeavor – the Plant Pathways Elucidation Project (P2EP). University scientists, industry leaders and college […]

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NC Research Campus launches plant project for college students

  Jennifer Thomas Staff Writer- Charlotte Business Journal Academic and industry partners at the N.C. Research Campus in Kannapolis have launched a $1.5 million initiative to engage college students from across the state in education and research. The program, called the Plant Pathways Elucidation Project, will center on how plants, including fruits and vegetables, benefit […]

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Strawberry breeding program receives national sustainability initiative grants

Fresh Plaza Dr. Jeremy Pattison, strawberry breeder and geneticist with the N.C. State University Plants for Human Health Institute at the N.C. Research Campus, recently was awarded a $158,391 grant from the National Strawberry Sustainability Initiative, and is a co-investigator on a second grant in the amount of $127,168, led by Dr. Brian Whipker, also […]

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Pathview: an R/Bioconductor package for pathway based data integration and visualization

Pathview: an R/Bioconductor package for pathway based data integration and visualization. Bioinformatics. Epub June 4, 2013. Luo W, Brouwer C. Department of Bioinformatics and Genomics, UNC Charlotte and NC Research Campus. Abstract SUMMARY: Pathview is a novel tool set for pathway-based data integration and visualization. It maps and renders user data on relevant pathway graphs. […]

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Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries ( Vaccinium spp.).

Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries ( Vaccinium spp.). Journal of Agricultural Food Chemistry. Epub May 13, 2013. Yousef GG, Brown AF, Funakoshi Y, Mbeunkui F, Grace MH, Ballington JR, Loraine A, Lila MA. Department of Horticultural Science and Department of Food Bioprocessing and […]

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Klebsiella Linked to Infant Melamine Deaths

The UNC Greensboro Center for Translational Biomedical Research and the David H. Murdock Research Institute in partnership with scientists from Shanghai Jiao Tong University in Shanghai, China and the Imperial College of London, United Kingdom have shed light on why so many babies who drank melamine-tainted milk in 2008 did not die. The bacteria Klebsiella terrigena […]

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Melamine-induced renal toxicity is mediated by the gut microbiota

Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. February 13, 2013. Zheng X,Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Luther M, Su M, Nicholson JK, Jia W. Shanghai Key Laboratory of Diabestes Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated […]

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The heterodimerization of platelet-derived chemokines

The heterodimerization of platelet-derived chemokines. Biochimica et Biophysica Acta (BBA)- Proteins and Proteomics. January 2013. James Carlson, Sarah A. Baxter, Didier Dréau, Irina V. Nesmelova. Analytical Sciences Laboratory, David H. Murdock Research Institute and the Department of Biology,  Department of Physics and Optical Science and the Center for Biomedical Engineering and Science, University of North […]

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DHMRI Advances Personalized Medicine in North Carolina

Personalized medicine is transforming healthcare by precipitating a shift to a model that takes into account individual differences and the influence of genetics and the environment. The advantage is more effective treatments, an enhanced ability to predict risk for chronic disease and the opportunity for earlier medical intervention. The David H. Murdock Research Institute (DHMRI) is […]

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Bananas For An Energy Boost

Scientists with the Appalachian State University Human Performance Lab and the Dole Foods Nutrition Research Laboratory published findings in May in the peer-reviewed online journal PloS One that proved scientifically what professional and recreational athletes have long believed- bananas are a good source of energy when exercising. The study showed that bananas provide the same energy boost as […]

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Exploring salivary proteomes in edentulous patients with type 2 diabetes

Exploring salivary proteomes in edentulous patients with type 2 diabetes. Mol Biosyst. April 2012, Border MB, Schwartz S, Carlson J, Dibble CF, Kohltfarber H, Offenbacher S, Buse JB, Bencharit S. Molecular Biosystems. David H. Murdock Research Institute. Abstract Type 2 diabetes and tooth loss are linked both epidemiologically and pathophysiologically. We applied label-free differential protein expression analysis […]

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Human gouty arthritis is associated with a distinct serum trace elemental profile

Human gouty arthritis is associated with a distinct serum trace elemental profile. Metallomics, March 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for Research Excellence in BioActive Food Components and David H. Murdock Research Institute. Abstract Homeostatic imbalance of essential trace elements […]

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Exercise Frequency Is Related to Psychopathology but not Neurocognitive Function.

Exercise Frequency Is Related to Psychopathology but not Neurocognitive Function. Medicine and Science in Sports Exercise, January 2012.Knab AM, Nieman DC, Broman-Fulks JJ, Canu WH, Sha W. Appalachian State University Human Performance Laboratory; Appalachian State University Department of Psychology, NC; and Bioinformatics Services Division, University of North Carolina at Charlotte, North Carolina Research Campus. Abstract […]

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Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery.

Barnes M R, Harland L, Foord S M, Hall M D, Dix I, Thomas S, Williams-Jones B I, Brouwer C R. (2009) Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery. Nat Rev Drug Discov. 8:701-708. Abstract Pharmaceutical research and development is facing substantial challenges that have prompted the industry to shift funding from early- […]

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Visualizing the drug target landscape.

Campbell S A, Gaulton A, Marshall J, Bichko D, Martin S, Brouwer C and Harland L. (2009) Visualizing the drug target landscape. Drug Disc Today. 15:3-15. Abstract Generating new therapeutic hypotheses for human disease requires the analysis and interpretation of many different experimental datasets. Assembling a holistic picture of the current landscape of drug discovery […]

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