Search Results for metformin

Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells

October 19, 2017

Nipun Saini and Xiaohe Yang (2017). Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells. Acta Biochimica et Biophysica Sinica. Author Affiliations Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, North Carolina Research Campus, Kannapolis, NC 28081, USA Abstract Metformin, a first line medication […]

Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells

October 12, 2017

Nipun Saini and Xiaohe Yang (2017). Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells. Acta Biochimica et Biophysica Sinica. Author Affiliations: Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, North Carolina Research Campus, Kannapolis, NC 28081, USA Abstract: Metformin, a first line medication […]

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

July 28, 2015

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models

December 09, 2013

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models. Cancer Prevention Research (Philadephia, PA). December 9, 2013. [Epub ahead of print] Zhu P, Davis M, Blackwelder A, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Julius L. Chambers Biomedical Biotechnology Research Institute, Julius L. Chambers Biomedical Biotechnology Research Institute/NC Central University Nutrition Research Program, NC Research […]

Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway.

August 17, 2017

Guo Z, Zhao M, Howard EW, Zhao Q, Parris AB, Ma Z, Yang X (2017). Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway. Oncotarget. Author Affiliations Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, Kannapolis, North Carolina, USA. Abstract […]

Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers

March 19, 2009

Bao, Y., Zhao, T., Wang, X., Qiu, Y., Su, M., Jia, W.*Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers, Journal of Proteome Research(IF = 5.675), 8(4), 1623-1630, 2009. Abstract The pathological development and the drug intervention of type 2 diabetes mellitus (T2DM) involve altered expression of downstream low molecular weight […]

Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifoliumAiton.

March 14, 2009

Grace, M., David M. Ribnicky, Peter Kuhn, Alex Poulev, Sithes Logendra, Gad G. Yousef, Ilya Raskin and Mary Ann Lila. 2009. Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifoliumAiton. Phytomedicine 16: 406-415. Abstract Blueberry fruits are known as a rich source of anthocyanin components. In this study we demonstrate that anthocyanins […]