Search Results for metformin

Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells

October 19, 2017

Nipun Saini and Xiaohe Yang (2017). Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells. Acta Biochimica et Biophysica Sinica. Author Affiliations Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, North Carolina Research Campus, Kannapolis, NC 28081, USA Abstract Metformin, a first line medication […]

Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells

October 12, 2017

Nipun Saini and Xiaohe Yang (2017). Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells. Acta Biochimica et Biophysica Sinica. Author Affiliations: Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, North Carolina Research Campus, Kannapolis, NC 28081, USA Abstract: Metformin, a first line medication […]

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

July 28, 2015

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models

December 09, 2013

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models. Cancer Prevention Research (Philadephia, PA). December 9, 2013. [Epub ahead of print] Zhu P, Davis M, Blackwelder A, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Julius L. Chambers Biomedical Biotechnology Research Institute, Julius L. Chambers Biomedical Biotechnology Research Institute/NC Central University Nutrition Research Program, NC Research […]

Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway.

August 17, 2017

Guo Z, Zhao M, Howard EW, Zhao Q, Parris AB, Ma Z, Yang X (2017). Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway. Oncotarget. Author Affiliations Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, Kannapolis, North Carolina, USA. Abstract […]

The Match Game

August 17, 2017

Read the original article by Lori Lesko from Drug Discovery News. KANNAPOLIS, N.C.—Mixing and matching or repurposing drugs developed for one disease to treat another is nothing new, but Dr. Xiaohe Yang, senior researcher and associate professor at North Carolina Central University (NCCU), may have come up with an ideal match. Yang has discovered that well-known […]

New Strategies for Breast Cancer Prevention Tied to Diabetes Drugs, Diet

June 08, 2017

Research by breast cancer expert Xiaohe Yang, M.D., Ph.D., shows that well-known drugs for type 2 diabetes and dietary factors may be the key to breast cancer prevention.    Kannapolis, N.C.– Research published in the last year by Xiaohe Yang, M.D., Ph.D., an associate professor at North Carolina Central University’s (NCCU) Nutrition Research Program at the North […]

Finding Strategies to Prevent Breast Cancer

March 02, 2017

Breast cancer expert Xiaohe Yang, MD, PhD, tackles this complex disease and the many factors involved in its treatment, prevention, and progression. Xiaohe Yang, MD, PhD, knows there is not a “one-size-fits-all” cure for breast cancer. He and his research team are instead identifying the factors involved in different breast cancer subtypes, testing novel preventative […]

Study Shows New Mechanism for the Prevention of HER2/neu Breast Cancer

March 11, 2015

According to the American Cancer Society, up to 30 percent of all breast cancer patients are HER2/neu positive. This means they have too much of the HER2/neu growth-promoting protein, which causes the development of an aggressive form of breast cancer. Although several drugs are available to treat HER2/neu producing breast cancer, such as Trastuzumab (Herceptin) […]

Making Healthy ‘Grits’ in Africa with Dr. Mary Ann Lila

May 22, 2014

By: David Hunt, Carolina Wild Nearly 8,000 miles, an ocean and seven time zones separate the small town of Kannapolis, N.C. from the heartland of southern Africa. Food scientist Mary Ann Lila knows the distance all too well. She’s visited 17 African countries in the past eight years. But she doesn’t measure the distance solely in miles. […]

Reaping a Healthy Harvest

April 07, 2014

<!– ­http://research.ncsu.edu/results/2014/04/healthy-harvest/ By David Hunt Nearly 8,000 miles, an ocean and seven time zones separate the small town of Kannapolis, N.C. from the heartland of southern Africa. Food scientist Mary Ann Lila knows the distance all too well. She’s visited 17 African countries in the past eight years. But she doesn’t measure the distance solely […]

NC Central University

January 09, 2014

NC Central University Nutrition Research Program NC Central University’s (NCCU) Nutrition Research Program is part of the Julius L. Chambers Biomedical Biotechnology Research Institute (BBRI) at the main campus of NCCU in Durham, NC. The BBRI conducts multidisciplinary and inter-institutional research focused on health issues that disproportionately affect minority and underserved populations while providing students […]

Blueberry Benefits

January 06, 2014

Growing Magazine – January, 2014 FEATURES Blueberry Benefits Researching the fruit’s health properties By Rocky Womack Click image to enlarge. Mary Ann Lila, director of the Plants for Human Health Institute at NCSU, says blueberries contain a variety of phytochemicals that may help people with cancer, cardiovascular disease, diabetes and obesity, to name a few. […]

Catalyst Group’s 2013 Symposium Celebrates NCRC Research

April 19, 2013

 NCRC The NC Research Campus Catalyst Group hosted their second annual research symposium, Celebrating Research and Collaborations at the NCRC, on Monday, April 15, 2013 in the core lab event room. The Catalyst Group, which fosters personal and professional relationships between researchers on campus, hosted 100 attendees who benefited from a poster competition, faculty presentations, […]

Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers

March 19, 2009

Bao, Y., Zhao, T., Wang, X., Qiu, Y., Su, M., Jia, W.*Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers, Journal of Proteome Research(IF = 5.675), 8(4), 1623-1630, 2009. Abstract The pathological development and the drug intervention of type 2 diabetes mellitus (T2DM) involve altered expression of downstream low molecular weight […]

Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifoliumAiton.

March 14, 2009

Grace, M., David M. Ribnicky, Peter Kuhn, Alex Poulev, Sithes Logendra, Gad G. Yousef, Ilya Raskin and Mary Ann Lila. 2009. Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifoliumAiton. Phytomedicine 16: 406-415. Abstract Blueberry fruits are known as a rich source of anthocyanin components. In this study we demonstrate that anthocyanins […]